Article

A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination

2021-04-11

Abstract excerpt

Mutations in the tumour suppressor gene BRCA2 are associated with predisposition to breast and ovarian cancers. BRCA2 has a central role in maintaining genome integrity by facilitating the repair of toxic DNA double-strand breaks (DSBs) by homologous recombination (HR). BRCA2 acts by promoting RAD51 nucleoprotein filament formation on resected single-stranded DNA, but how BRCA2 activity is regulated during HR is n...

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Literature Corpus work: e4ecc065-2510-502b-ae72-c5d72b6062cc
DOI: 10.1101/2021.04.10.439193

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