Article
Hyperphosphorylation of the BARD1 tumor suppressor in mitotic cells.
The Journal of biological chemistry - 1 Jul 2005
Choudhury Atish D, Xu Hong, Modi Ami P, Zhang Wenzhu, Ludwig Thomas, Baer Richard
Abstract excerpt
Although the BRCA1 tumor suppressor has been implicated in a number of cellular processes, it plays an especially important role in the DNA damage response as a regulator of cell cycle checkpoints and DNA repair pathways. In vivo, BRCA1 exists as a heterodimer with the BARD1 protein, and many of its biological functions are mediated by the BRCA1-BARD1 complex. Here, we show that BARD1 is phosphorylated in a cell...
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