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Article

Detection of somatic mutations in vivo in lung fibroblasts, I. Spontaneous frequencies in Chinese hamsters and F344 rats.

Mutation research - 1 Dec 1992

Heddle J A, Gingerich J D, Urlando C, Pagura M, Shepson P, Khan M A

Abstract excerpt

The frequency of mutant cells observed in a series of experiments in which primary cells were isolated from untreated or solvent control animals are reported. The mutants detected are thioguanine-resistant lung fibroblasts isolated de novo from Chinese hamsters or Fischer 344 rats. The results in the two species were very similar. The distribution of mutant colonies in cells isolated from untreated animals is not...

Topics

Animals
Cells, Cultured
Cricetinae
Cricetulus
Female
Fibroblasts
Genetic Variation
Lung
Male
Mutagenicity Tests
Rats
Rats, Inbred F344

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sex Characteristics

Solvents

Species Specificity

Source

Identifiers

PMID: 1281265
DOI: 10.1016/0165-1161(92)91532-v

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1281265-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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