Article
Spontaneous mutation during fetal development and post-natal growth.
Mutagenesis - 1 Nov 1998
Paashuis-Lew Y R, Heddle J A
Abstract excerpt
Somatic mutations seem to accumulate slowly with age during adult life in both mice and men. There is, however, a substantial mutant frequency at birth, suggesting that the rate of accumulation is much higher before birth. This suggests that DNA replication plays an important role in the generation of spontaneous mutations. Since most cell division and accompanying DNA replication occurs early in development,...
Topics
- Animals
- Animals, Newborn
- DNA Adducts
- Embryonic and Fetal Development
- Ethylnitrosourea
- Female
- Gestational Age
- Intestines
- Male
- Mice
- Mice, Inbred Strains
- Mice, Transgenic