Factors affecting somatic mutation frequencies in vivo.

doi:10.1016/0921-8734(95)00024-z

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Factors affecting somatic mutation frequencies in vivo.

Mutation research - 1 Oct 1995

Zhang X B, Urlando C, Tao K S, Heddle J A

Abstract excerpt

The factors that influence the spontaneous mutant frequencies in mammalian tissues have been ranked on the basis of data from our laboratory together with published data. Some of the data come from the endogenous hprt and Dlb-1 loci, but most come from transgenic mice carrying the bacterial lacI and lacZ genes in recoverable lambda phage vectors. Since there is evidence that these bacterial loci are selectively...

Topics

Aging
Animals
Bacterial Proteins
Escherichia coli Proteins
Female
Humans
Hypoxanthine Phosphoribosyltransferase
Intestine, Small
Lac Operon
Lac Repressors
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred Strains

Mice, Transgenic

Mutation

Repressor Proteins

Spleen

Transgenes

Source

Open in PubMed

Identifiers

PMID: 7565874
DOI: 10.1016/0921-8734(95)00024-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7565874-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Factors affecting somatic mutation frequencies in vivo.PMID 7565874Read ↗

Estimation of mutation frequencies in normal mammalian cells and the development of cancer.Semantic proximity Read ↗

Tissue-specific time courses of spontaneous mutation frequency and deviations in mutation pattern are observed in middle to late adulthood in Big Blue mice.Semantic proximity Read ↗

Age- and temperature-dependent somatic mutation accumulation in Drosophila melanogaster.Semantic proximity Read ↗

Risk estimation from somatic mutation assays.Semantic proximity Read ↗

Sequence spectra of spontaneous lacZ gene mutations in transgenic mouse somatic and germline tissues.Semantic proximity Read ↗

Use of transgenic mouse models for studying somatic mutations in aging.Semantic proximity Read ↗

Age-associated increase of spontaneous mutant frequency and molecular nature of mutation in newborn and old lacZ-transgenic mouse.Semantic proximity Read ↗

Spontaneous mutation in lacI transgenic mice: a comparison of tissues.Semantic proximity Read ↗

Spontaneous mutation in Big Blue transgenic mice: analysis of age, gender, and tissue type.Semantic proximity Read ↗

Comparison of somatic mutation in a transgenic versus host locus.Semantic proximity Read ↗

Temporal and molecular characteristics of lacZ mutations in somatic tissues of transgenic mice.Semantic proximity Read ↗

Comparison of mutation frequencies obtained using transgenes and specific-locus mutation systems in male mouse germ cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.