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Article

Runx1/AML1 hematopoietic transcription factor contributes to skeletal development in vivo

10 Jun 2003

Abstract excerpt

The requirement of Runx2 (Cbfal/AML3), a runt homology domain transcription factor essential for bone formation and osteoblast differentiation, is well established. Although Runx2 is expressed in the developing embryo prior to ossification, yet in the absence of Runx2 initial formation of the skeleton is normal, suggesting a potential redundancy in function of Runx family members. Here we addressed expression of...

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PMID: 12811823
DOI: 10.1002/jcp.10316

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