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Article

Runx1 dose-dependently regulates endochondral ossification during skeletal development and fracture healing.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 2012

Soung Do Y, Talebian Laleh, Matheny Christina J, Guzzo Rosa, Speck Maren E, Lieberman Jay R, Speck Nancy A, Drissi Hicham

Abstract excerpt

Runx1 is expressed in skeletal elements, but its role in fracture repair has not been analyzed. We created mice with a hypomorphic Runx1 allele (Runx1(L148A) ) and generated Runx1(L148A/-) mice in which >50% of Runx1 activity was abrogated. Runx1(L148A/-) mice were viable but runted. Their growth plates had extended proliferating and hypertrophic zones, and the percentages of Sox9-, Runx2-, and Runx3-positive...

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Identifiers

PMID: 22431360
DOI: 10.1002/jbmr.1601
PMCID: PMC3377839

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