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The roles of Runx1 in skeletal development and osteoarthritis: A concise review

1 Dec 2022

Abstract excerpt

Runt-related transcription factor-1 (Runx1) is well known for its functions in hematopoiesis and leukemia but recent research has focused on its role in skeletal development and osteoarthritis (OA). Deficiency of the Runx1 gene is fatal in early embryonic development, and specific knockout of Runx1 in cell lineages of cartilage and bone leads to delayed cartilage formation and impaired bone calcification. Runx1...

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PMID: 36636224
DOI: 10.1016/j.heliyon.2022.e12656

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