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Microarray analysis on Runx2-deficient mouse embryos reveals novel Runx2 functions and target genes during intramembranous and endochondral bone formation.

Bone - 1 Oct 2006

Vaes Bart L T, Ducy Patricia, Sijbers Anneke M, Hendriks José M A, van Someren Eugene P, de Jong Nanning G, van den Heuvel Edwin R, Olijve Wiebe, van Zoelen Everardus J J, Dechering Koen J

Abstract excerpt

A major challenge in developmental biology is to correlate genome-wide gene expression modulations with developmental processes in vivo. In this study, we analyzed the role of Runx2 during intramembranous and endochondral bone development, by comparing gene expression profiles in 14.5 dpc wild-type and Runx2 (-/-) mice. A total of 1277, 606 and 492 transcripts were found to be significantly modulated by Runx2 in...

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PMID: 16774856
DOI: 10.1016/j.bone.2006.04.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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