Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vav1 oncogenic mutation inhibits T cell receptor-induced calcium mobilization through inhibition of phospholipase Cγ1 activation.

The Journal of biological chemistry - 1 Jun 2012

Knyazhitsky Mira, Moas Etay, Shaginov Ekaterina, Luria Anna, Braiman Alex

Abstract excerpt

Robust elevation of the cytosolic calcium concentration is a crucial early step for T cell activation triggered by the T cell antigen receptor. Vav1 is a proto-oncogene expressed in hematopoietic cells that is indispensable for transducing the calcium-mobilizing signal. Following T cell receptor stimulation, Vav1 facilitates formation of signaling microclusters through multiple interactions with other proteins...

Topics

Join the communities discussing this publication.

Calcium
Enzyme Activation
Inositol 1,4,5-Trisphosphate
Lymphocyte Activation
Phospholipase C gamma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Mas

Proto-Oncogene Proteins c-vav

Receptors, Antigen, T-Cell

Source

Open in PubMed Open full text

Identifiers

PMID: 22474331
DOI: 10.1074/jbc.M111.309799
PMCID: PMC3366006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vav1 oncogenic mutation inhibits T cell receptor-induced calcium mobilization through inhibition of phospholipase Cγ1 activation.PMID 22474331Read ↗

The N-terminal 20-amino acid region of guanine nucleotide exchange factor Vav1 plays a distinguished role in T cell receptor-mediated calcium signaling.Semantic proximity Read ↗

New insights into the Vav1 activation cycle in lymphocytes.Semantic proximity Read ↗

Structural determinants for the biological activity of Vav proteins.Semantic proximity Read ↗

Function of the nucleotide exchange activity of vav1 in T cell development and activation.Semantic proximity Read ↗

Tyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activity.Semantic proximity Read ↗

Vav1: A Dr. Jekyll and Mr. Hyde protein--good for the hematopoietic system, bad for cancer.Semantic proximity Read ↗

Vav1 mutations: What makes them oncogenic?Semantic proximity Read ↗

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product.Semantic proximity Read ↗

Mutation of Vav1 adaptor region reveals a new oncogenic activation.Semantic proximity Read ↗

The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways.Semantic proximity Read ↗

Design, Assessment, and in vivo Evaluation of a Computational Model Illustrating the Role of CAV1 in CD4+ T-lymphocytesSemantic proximity Read ↗

Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.