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Article

SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1.

Molecular cell - 13 Mar 2009

Woodcock Simon A, Rooney Claire, Liontos Michalis, Connolly Yvonne, Zoumpourlis Vassilis, Whetton Anthony D, Gorgoulis Vassilis G, Malliri Angeliki

Abstract excerpt

The Rac activator Tiam1 is required for adherens junction (AJ) maintenance, and its depletion results in AJ disassembly. Conversely, the oncoprotein Src potently induces AJ disassembly and epithelial-mesenchymal transition (EMT). Here, we show that Tiam1 is phosphorylated on Y384 by Src. This occurs predominantly at AJs, is required for Src-induced AJ disassembly and cell migration, and creates a docking site on...

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Source

Identifiers

PMID: 19285946
DOI: 10.1016/j.molcel.2009.02.012

Genes

SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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