Article
Rapid detection of the known SNPs of CYP2C9 using oligonucleotide microarray.
World journal of gastroenterology - 1 Jun 2003
Wen Si-Yuan, Wang Hui, Sun Ou-Jun, Wang Sheng-Qi
Abstract excerpt
AIM: Cytochrome P450 2C9 (CYP2C9) is a polymorphic enzyme responsible for the metabolism of a large number of clinically important drugs. Individuals with mutant enzymes may risk serious side effects under routine therapy with certain drugs metabolized by CYP2C9. In order to facilitate the detection of the known SNPs of CYP2C9, an allele-specific oligonucleotide (ASO) based microarray was made. METHODS: An...
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