Article
Effects of the CYP2C9*13 allele on the pharmacokinetics of losartan in healthy male subjects.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Oct 2009
Li Z, Wang G, Wang L-S, Zhang W, Tan Z-R, Fan L, Chen B-L, Li Q, Liu J, Tu J-H, Hu D-L, Liu Z-Q, Zhou H-H
Abstract excerpt
The aim of the study was to determine the pharmacokinetics of losartan in relation to the CYP2C9*13 allele. A single oral dose of 50 mg losartan was administrated to each of the 16 healthy male volunteers with a different genotype (CYP2C9*1/*1, n = 6; CYP2C9*1/*13, n = 4; and CYP2C9*1/*3, n = 6)....
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