Article
Search for the molecular basis of ultra-rapid CYP2C9-catalysed metabolism: relationship between SNP IVS8-109A>T and the losartan metabolism phenotype in Swedes.
European journal of clinical pharmacology - 1 Jul 2012
Hatta Fazleen H M, Teh Lay Kek, Helldén Anders, Hellgren Karin Engström, Roh Hyung-Keun, Salleh Mohd Zaki, Aklillu Eleni, Bertilsson Leif
Abstract excerpt
AIM: To search for a relationship between ultra-rapid metabolism catalysed by cytochrome P450 2C9 (CYP2C9) and its genotypes. METHODS: DNA from a Swedish ultra-rapid metaboliser patient [losartan metabolic ratio (MR) <0.13] and three healthy Swedes with normal CYP2C9 activity and a MR of about 1 were assessed for variation in the CYP2C9 gene. Direct DNA sequencing was performed for all exons and exon-intron...
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