Article
Development of an electrochemical DNA-based biosensor for the detection of the cardiovascular pharmacogenetic-altering SNP CYP2C9*3.
Talanta - 1 Nov 2023
Morais Stephanie L, Magalhães Júlia M C S, Domingues Valentina F, Delerue-Matos Cristina, Ramos-Jesus Joilson, Ferreira-Fernandes Hygor, Pinto Giovanny R, Santos Marlene, Barroso M Fátima
Abstract excerpt
Cardiovascular diseases are among the major causes of mortality and morbidity. Warfarin is often prescribed for these disorders, an anticoagulant with inter and intra-dosage variability dose required to achieve the target international normalized ratio. Warfarin presents a narrow therapeutic index, and due to its variability, it can often be associated with the risk of hemorrhage, or in other patients,...
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