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Article

Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma.

The American journal of pathology - 1 Feb 1999

Rimm D L, Caca K, Hu G, Harrison F B, Fearon E R

Abstract excerpt

Beta-Catenin has a critical role in E-cadherin-mediated cell-cell adhesion, and it also functions as a downstream signaling molecule in the wnt pathway. Mutations in the putative glycogen synthase kinase 3beta phosphorylation sites near the beta-catenin amino terminus have been found in some cancers and cancer cell lines. The mutations render beta-catenin resistant to regulation by a complex containing the...

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Identifiers

PMID: 10027390
DOI: 10.1016/s0002-9440(10)65278-9
PMCID: PMC1850000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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