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Article

Frequent mutations in the beta-catenin gene in desmoid tumors from patients without familial adenomatous polyposis.

Oncology research - 1 Jan 1998

Miyoshi Y, Iwao K, Nawa G, Yoshikawa H, Ochi T, Nakamura Y

Abstract excerpt

Mutations in the APC gene contribute to development of sporadic desmoid tumors as well as to the hereditary tumors that usually accompany familial adenomatous polyposis (FAP). Adenomatous polyposis coli (APC) mutations cause an intracellular accumulation of beta-catenin that results in abnormal signaling in the wnt/wingless pathway. Mutations of the beta-catenin gene itself have also been noted in several types...

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Share to Adenomatous Polyposis Coli
Share to beta Catenin
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10367940

Genes

APC
FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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