Article
Genetic bottlenecks in intraspecies virus transmission.
Current opinion in virology - 1 Feb 2018
McCrone John T, Lauring Adam S
Abstract excerpt
Ultimately, viral evolution is a consequence of mutations that arise within and spread between infected hosts. The transmission bottleneck determines how much of the viral diversity generated in one host passes to another during transmission. It therefore plays a vital role in linking within-host processes to larger evolutionary trends. Although many studies suggest that transmission severely restricts the amount...
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