Article
Genetic susceptibility to dupuytren disease: association of Zf9 transcription factor gene.
Plastic and reconstructive surgery - 1 Jun 2003
Bayat Ardeshir, Watson J Stewart, Stanley John K, Ferguson Mark W J, Ollier William E R
Abstract excerpt
Transforming growth factor beta 1 (TGF-beta 1) is a key fibrogenic cytokine that has been shown to stimulate fibroblast proliferation and extracellular matrix deposition and has been implicated in the pathogenesis of Dupuytren disease. Zf9 is a transcription factor that increases TGF-beta 1 expression in tissue. The authors previously demonstrated a lack of association between common TGF-beta 1 and TGF-beta 2...
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