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Article

Using functional genomics to identify drug targets: a Dupuytren's disease example.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

Sedic Mirela, Pavelic Sandra Kraljevic, Hock Karlo

Abstract excerpt

Research into the molecular mechanism of Dupuytren's disease (DD) illustrates all the problems common to drug discovery in orphan diseases, but also in more commonly investigated ailments. Current findings characterize DD as a disease with complex molecular pathology, with changes in expression of multiple genes and proteins as well as many contributing risk factors. Some of the observed changes include genes and...

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PMID: 22821590
DOI: 10.1007/978-1-61779-965-5_2

Genes

ADAM12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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