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Article

A genome-wide association meta-analysis implicates Hedgehog and Notch signaling in Dupuytren's disease.

Nature communications - 3 Jan 2024

Riesmeijer Sophie A, Kamali Zoha, Ng Michael, Drichel Dmitriy, Piersma Bram, Becker Kerstin, Layton Thomas B, Nanchahal Jagdeep, Nothnagel Michael, Vaez Ahmad, Hennies Hans Christian, Werker Paul M N, Furniss Dominic, Nolte Ilja M

Abstract excerpt

Dupuytren's disease (DD) is a highly heritable fibrotic disorder of the hand with incompletely understood etiology. A number of genetic loci, including Wnt signaling members, have been previously identified. Our overall aim was to identify novel genetic loci, to prioritize genes within the loci for functional studies, and to assess genetic correlation with associated disorders. We performed a meta-analysis of six...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38172110
DOI: 10.1038/s41467-023-44451-0
PMCID: PMC10764787

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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