Article
Wnt signaling and Dupuytren's disease.
The New England journal of medicine - 28 Jul 2011
Dolmans Guido H, Werker Paul M, Hennies Hans C, Furniss Dominic, Festen Eleonora A, Franke Lude, Becker Kerstin, van der Vlies Pieter, Wolffenbuttel Bruce H, Tinschert Sigrid, Toliat Mohammad R, Nothnagel Michael, Franke Andre, Klopp Norman, Wichmann H-Erich, Nürnberg Peter, Giele Henk, Ophoff Roel A, Wijmenga Cisca
Abstract excerpt
BACKGROUND: Dupuytren's disease is a benign fibromatosis of the hands and fingers that leads to flexion contractures. We hypothesized that multiple genetic and environmental factors influence susceptibility to this disease and sought to identify susceptibility genes to better understand its pathogenesis. METHODS: We conducted a genomewide association study of 960 Dutch persons with Dupuytren's disease and 3117...
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