Article

A meta-analysis of genome-wide association studies in 614,243 individuals identifies 59 novel susceptibility loci underlying Dupuytren’s contracture

2022-06-09

Abstract excerpt

Dupuytren’s contracture or disease (DD) is a disabling, fibroproliferative disease of the hand that affects up to 25% of people of northwestern European descent. It typically manifests in adulthood and many affected individuals have a positive family history, yet the genetic architecture of DD is not completely understood. We conducted genome-wide association studies (GWAS) of DD in 8,846 cases and 347,659 populat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 18c12a0c-b942-5b54-a884-30c9be4d3a63
DOI: 10.1101/2022.06.07.22276119

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A meta-analysis of genome-wide association studies in 614,243 individuals identifies 59 novel susceptibility loci underlying Dupuytren’s contractureDOI 10.1101/2022.06.07.22276119Read

A genome-wide association meta-analysis implicates Hedgehog and Notch signaling in Dupuytren's disease.Semantic proximity Read

A Genome-wide Association Study of Dupuytren Disease Reveals 17 Additional Variants Implicated in Fibrosis.Semantic proximity Read

Integrative analysis of Dupuytren’s disease identifies novel risk locus and reveals a shared genetic etiology with BMISemantic proximity Read

Genome-Wide Analysis Using Exon Arrays Demonstrates an Important Role for Expression of Extra-Cellular Matrix, Fibrotic Control and Tissue Remodelling Genes in Dupuytren's DiseaseSemantic proximity Read

Molecular genetics of Dupuytren’s contractureSemantic proximity Read

Meta-Analysis of Genome-Wide Association Studies and Network Analysis-Based Integration with Gene Expression Data Identify New Suggestive Loci and Unravel a Wnt-Centric Network Associated with Dupuytren's Disease.Semantic proximity Read

Recent advances in the understanding of Dupuytren’s diseaseSemantic proximity Read

Wnt signaling and Dupuytren's disease.Semantic proximity Read

Dupuytren diathesis and genetic risk.Semantic proximity Read

Investigating the genetic basis of fibrotic pathway dysregulation in Dupuytren's contracture.Semantic proximity Read

Dupuytren's disease: a localised and accessible human fibrotic disorderSemantic proximity Read

Scientific understanding and clinical management of Dupuytren disease.Semantic proximity Read