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Integrative analysis of Dupuytren’s disease identifies novel risk locus and reveals a shared genetic etiology with BMI

2018-12-18

Abstract excerpt

Dupuytren’s disease is the common inherited tissue-specific fibrotic disorder. It’s characterized by progressive and irreversible fibroblastic proliferation affecting the palmar fascia of the hand, with an onset typically in the sixth decade of life. Although genome-wide association studies (GWAS) have identified 24 genomic regions associated with Dupuytren’s risk, the biological mechanisms driving signal at these...

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Literature Corpus work
c62d09bd-4732-5723-b654-6376817950ff
DOI
10.1101/499368
Open publication

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