Article
A temperature-sensitive mutation in the nodal-related gene cyclops reveals that the floor plate is induced during gastrulation in zebrafish.
Development (Cambridge, England) - 1 Jul 2003
Tian Jing, Yam Caleb, Balasundaram Gayathri, Wang Hui, Gore Aniket, Sampath Karuna
Abstract excerpt
The floor plate, a specialized group of cells in the ventral midline of the neural tube of vertebrates, plays crucial roles in patterning the central nervous system. Recent work from zebrafish, chick, chick-quail chimeras and mice to investigate the development of the floor plate have led to several models of floor-plate induction. One model suggests that the floor plate is formed by inductive signalling from the...
Topics
- Alleles
- Animals
- COS Cells
- Chromosome Mapping
- Gastrula
- Genotype
- Homozygote
- In Situ Hybridization
- Intracellular Signaling Peptides and Proteins
- Microscopy, Fluorescence
- Models, Genetic
- Mutation
- Neural Crest