Article
Vertebrate floor-plate specification: variations on common themes.
Trends in genetics : TIG - 1 Mar 2004
Strähle Uwe, Lam Chen Sok, Ertzer Raymond, Rastegar Sepand
Abstract excerpt
Situated at the ventral-most part of the vertebrate neural tube, the floor plate (FP) is an important signalling centre that controls the regional differentiation of neurons in the nervous system. It secretes guidance molecules that direct ventrally navigating axons crucial for the correct wiring of neuronal circuits. Although the function of the FP is well-conserved from fish to humans, discrepancies exists with...
Topics
- Animals
- Axons
- Cell Differentiation
- Chick Embryo
- Fishes
- Genetic Variation
- Humans
- Mice
- Mice, Mutant Strains
- Neurons
- Zebrafish