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Article

Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling.

Nature - 10 Sept 1998

Sampath K, Rubinstein A L, Cheng A M, Liang J O, Fekany K, Solnica-Krezel L, Korzh V, Halpern M E, Wright C V

Abstract excerpt

Zebrafish cyclops (cyc) mutations cause deficiencies in the dorsal mesendoderm and ventral neural tube, leading to neural defects and cyclopia. Here we report that cyc encodes a transforming growth factor-beta (TGF-beta)-related intercellular signalling molecule that is similar to mouse nodal. cyc is expressed in dorsal mesendoderm at gastrulation and in the prechordal plate until early somitogenesis. Expression...

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Identifiers

PMID: 9744278
DOI: 10.1038/26020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling.PMID 9744278Read ↗

Direct action of the nodal-related signal cyclops in induction of sonic hedgehog in the ventral midline of the CNS.Semantic proximity Read ↗

Cyclops-independent floor plate differentiation in zebrafish embryos.Semantic proximity Read ↗

cyclops encodes a nodal-related factor involved in midline signaling.Semantic proximity Read ↗

Goosecoid expression in neurectoderm and mesendoderm is disrupted in zebrafish cyclops gastrulas.Semantic proximity Read ↗

Midline signaling in the primordium of the zebrafish anterior central nervous system.Semantic proximity Read ↗

A temperature-sensitive mutation in the nodal-related gene cyclops reveals that the floor plate is induced during gastrulation in zebrafish.Semantic proximity Read ↗

Zebrafish organizer development and germ-layer formation require nodal-related signals.Semantic proximity Read ↗

Complex expression of the zp-50 pou gene in the embryonic zebrafish brain is altered by overexpression of sonic hedgehog.Semantic proximity Read ↗

Nodal signaling and the zebrafish organizer.Semantic proximity Read ↗

The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system.Semantic proximity Read ↗

The EGF-CFC protein one-eyed pinhead is essential for nodal signaling.Semantic proximity Read ↗

The zebrafish nodal-related gene southpaw is required for visceral and diencephalic left-right asymmetry.Semantic proximity Read ↗

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