Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling.

doi:10.1038/26020

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Article

Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling.

Nature - 10 Sept 1998

Sampath K, Rubinstein A L, Cheng A M, Liang J O, Fekany K, Solnica-Krezel L, Korzh V, Halpern M E, Wright C V

Abstract excerpt

Zebrafish cyclops (cyc) mutations cause deficiencies in the dorsal mesendoderm and ventral neural tube, leading to neural defects and cyclopia. Here we report that cyc encodes a transforming growth factor-beta (TGF-beta)-related intercellular signalling molecule that is similar to mouse nodal. cy...

Topics

Animals
Body Patterning
Brain
Embryonic Induction
Gastrula
Hedgehog Proteins
Intracellular Signaling Peptides and Proteins
Mesoderm
Molecular Sequence Data
Mutation
Nodal Protein
Protein Biosynthesis
Signal Transduction
Trans-Activators
Transforming Growth Factor beta

Source

Open in PubMed

Identifiers

PMID: 9744278
DOI: 10.1038/26020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9744278-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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