Article
one-eyed pinhead is required for development of the ventral midline of the zebrafish (Danio rerio) neural tube.
Genes and function - 1 Apr 1997
Strähle U, Jesuthasan S, Blader P, Garcia-Villalba P, Hatta K, Ingham P W
Abstract excerpt
Axial midline structures play a central role as signalling centres during the development of the vertebrate embryo. We have isolated mutant alleles of a new locus, one-eyed pinhead (oep), in the zebrafish that are characterized by cyclopia and impaired development of the floor plate. oep mutants...
Topics
- Alleles
- Animals
- Body Patterning
- Chimera
- Hedgehog Proteins
- Homeodomain Proteins
- Homozygote
- Mutagenesis
- Mutation
- Nervous System
- Proteins
- Signal Transduction
- Trans-Activators
- Transcription Factors
- Zebrafish
- Zebrafish Proteins