Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

one-eyed pinhead is required for development of the ventral midline of the zebrafish (Danio rerio) neural tube.

Genes and function - 1 Apr 1997

Strähle U, Jesuthasan S, Blader P, Garcia-Villalba P, Hatta K, Ingham P W

Abstract excerpt

Axial midline structures play a central role as signalling centres during the development of the vertebrate embryo. We have isolated mutant alleles of a new locus, one-eyed pinhead (oep), in the zebrafish that are characterized by cyclopia and impaired development of the floor plate. oep mutants fail to establish expression of axial (zebrafish HNF3beta) and sonic hedgehog in the midline of the neural plate but...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Homeodomain Proteins
Share to Homozygote

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutagenesis

Share to Mutation

Share to Proteins

Share to Signal Transduction

Share to Transcription Factors

Source

Identifiers

PMID: 9680314
DOI: 10.1046/j.1365-4624.1997.00010.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

one-eyed pinhead is required for development of the ventral midline of the zebrafish (Danio rerio) neural tube.PMID 9680314Read ↗

The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tail.Semantic proximity Read ↗

Mutations affecting development of the midline and general body shape during zebrafish embryogenesis.Semantic proximity Read ↗

Mosaic analysis with oep mutant reveals a repressive interaction between floor-plate and non-floor-plate mutant cells in the zebrafish neural tube.Semantic proximity Read ↗

Two distinct cell populations in the floor plate of the zebrafish are induced by different pathways.Semantic proximity Read ↗

Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio.Semantic proximity Read ↗

Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation.Semantic proximity Read ↗

Expression of axial and sonic hedgehog in wildtype and midline defective zebrafish embryos.Semantic proximity Read ↗

Phenotypic effects in Xenopus and zebrafish suggest that one-eyed pinhead functions as antagonist of BMP signalling.Semantic proximity Read ↗

Expression and regulation of a netrin homologue in the zebrafish embryo.Semantic proximity Read ↗

Disruption of Fuz in mouse embryos generates hypoplastic hindbrain development and reduced cranial nerve gangliaSemantic proximity Read ↗

Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning.Semantic proximity Read ↗

The EGF-CFC protein one-eyed pinhead is essential for nodal signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.