Article
Direct action of the nodal-related signal cyclops in induction of sonic hedgehog in the ventral midline of the CNS.
Development (Cambridge, England) - 1 Sept 2000
Müller F, Albert S, Blader P, Fischer N, Hallonet M, Strähle U
Abstract excerpt
The secreted molecule Sonic hedgehog (Shh) is crucial for floor plate and ventral brain development in amniote embryos. In zebrafish, mutations in cyclops (cyc), a gene that encodes a distinct signal related to the TGF(beta) family member Nodal, result in neural tube defects similar to those of shh null mice. cyc mutant embryos display cyclopia and lack floor plate and ventral brain regions, suggesting a role for...
Topics
- Animals
- Biomarkers
- Central Nervous System
- Chick Embryo
- Cyclic AMP-Dependent Protein Kinases
- DNA-Binding Proteins
- Embryo, Nonmammalian
- Enhancer Elements, Genetic
- Forkhead Transcription Factors
- Gene Expression Regulation, Developmental
- Genes, Reporter
- Hedgehog Proteins