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Article

Direct action of the nodal-related signal cyclops in induction of sonic hedgehog in the ventral midline of the CNS.

Development (Cambridge, England) - 1 Sept 2000

Müller F, Albert S, Blader P, Fischer N, Hallonet M, Strähle U

Abstract excerpt

The secreted molecule Sonic hedgehog (Shh) is crucial for floor plate and ventral brain development in amniote embryos. In zebrafish, mutations in cyclops (cyc), a gene that encodes a distinct signal related to the TGF(beta) family member Nodal, result in neural tube defects similar to those of shh null mice. cyc mutant embryos display cyclopia and lack floor plate and ventral brain regions, suggesting a role for...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclic AMP-Dependent Protein Kinases

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Source

Identifiers

PMID: 10952887
DOI: 10.1242/dev.127.18.3889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Direct action of the nodal-related signal cyclops in induction of sonic hedgehog in the ventral midline of the CNS.PMID 10952887Read ↗

Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling.Semantic proximity Read ↗

Cyclops-independent floor plate differentiation in zebrafish embryos.Semantic proximity Read ↗

A temperature-sensitive mutation in the nodal-related gene cyclops reveals that the floor plate is induced during gastrulation in zebrafish.Semantic proximity Read ↗

cyclops encodes a nodal-related factor involved in midline signaling.Semantic proximity Read ↗

Midline signaling in the primordium of the zebrafish anterior central nervous system.Semantic proximity Read ↗

Two distinct cell populations in the floor plate of the zebrafish are induced by different pathways.Semantic proximity Read ↗

The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system.Semantic proximity Read ↗

Nodal signaling and the zebrafish organizer.Semantic proximity Read ↗

Goosecoid expression in neurectoderm and mesendoderm is disrupted in zebrafish cyclops gastrulas.Semantic proximity Read ↗

Complex expression of the zp-50 pou gene in the embryonic zebrafish brain is altered by overexpression of sonic hedgehog.Semantic proximity Read ↗

The role of Sonic hedgehog in normal and abnormal craniofacial morphogenesisSemantic proximity Read ↗

Zebrafish wnt4b expression in the floor plate is altered in sonic hedgehog and gli-2 mutants.Semantic proximity Read ↗

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