Article
Cyclops-independent floor plate differentiation in zebrafish embryos.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jan 2003
Albert Stéphanie, Müller Ferenc, Fischer Nadine, Biellmann Dominique, Neumann Carl, Blader Patrick, Strähle Uwe
Abstract excerpt
In zebrafish, development of the ventral neural tube depends on the Nodal-related signal Cyclops (Cyc). One-day-old cyc mutant embryos lack the medial floor plate (MFP). We show here that cells expressing MFP marker genes differentiate gradually in cyc mutant embryos in a delayed manner during the second day of development. This late differentiation is restricted to the hindbrain and spinal cord and depends on an...
Topics
- Alleles
- Animals
- Cell Differentiation
- Embryo, Nonmammalian
- Gene Expression Regulation, Developmental
- Intracellular Signaling Peptides and Proteins
- Microscopy, Video
- Mutation
- Neural Crest
- Rhombencephalon
- Signal Transduction
- Spinal Cord
- Time Factors