Article
Cyclops-independent floor plate differentiation in zebrafish embryos.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jan 2003
Albert Stéphanie, Müller Ferenc, Fischer Nadine, Biellmann Dominique, Neumann Carl, Blader Patrick, Strähle Uwe
Abstract excerpt
In zebrafish, development of the ventral neural tube depends on the Nodal-related signal Cyclops (Cyc). One-day-old cyc mutant embryos lack the medial floor plate (MFP). We show here that cells expressing MFP marker genes differentiate gradually in cyc mutant embryos in a delayed manner during the second day of development. This late differentiation is restricted to the hindbrain and spinal cord and depends on an...
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