Article
Mutations affecting development of the midline and general body shape during zebrafish embryogenesis.
Development (Cambridge, England) - 1 Dec 1996
Brand M, Heisenberg C P, Warga R M, Pelegri F, Karlstrom R O, Beuchle D, Picker A, Jiang Y J, Furutani-Seiki M, van Eeden F J, Granato M, Haffter P, Hammerschmidt M, Kane D A, Kelsh R N, Mullins M C, Odenthal J, Nüsslein-Volhard C
Abstract excerpt
Tissues of the dorsal midline of vertebrate embryos, such as notochord and floor plate, have been implicated in inductive interactions that pattern the neural tube and somites. In our screen for embryonic visible mutations in the zebrafish we found 113 mutations in more than 27 genes with altered body shape, often with additional defects in CNS development. We concentrated on a subgroup of mutations in ten genes...
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