Article
Photic induction of mPer1 and mPer2 in cry-deficient mice lacking a biological clock.
Science (New York, N.Y.) - 24 Dec 1999
Okamura H, Miyake S, Sumi Y, Yamaguchi S, Yasui A, Muijtjens M, Hoeijmakers J H, van der Horst G T
Abstract excerpt
Mice lacking mCry1 and mCry2 are behaviorally arrhythmic. As shown here, cyclic expression of the clock genes mPer1 and mPer2 (mammalian Period genes 1 and 2) in the suprachiasmatic nucleus and peripheral tissues is abolished and mPer1 and mPer2 mRNA levels are constitutively high. These findings...
Topics
- Animals
- Biological Clocks
- Cell Cycle Proteins
- Circadian Rhythm
- Cryptochromes
- Drosophila Proteins
- Eye Proteins
- Feedback
- Flavoproteins
- Gene Expression Regulation
- In Situ Hybridization
- Light
- Liver
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mutation
- Nuclear Proteins