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Article

Targeted disruption of the mPer3 gene: subtle effects on circadian clock function.

Molecular and cellular biology - 1 Sept 2000

Shearman L P, Jin X, Lee C, Reppert S M, Weaver D R

Abstract excerpt

Neurons in the mammalian suprachiasmatic nucleus (SCN) contain a cell-autonomous circadian clock that is based on a transcriptional-translational feedback loop. The basic helix-loop-helix-PAS proteins CLOCK and BMAL1 are positive regulators and drive the expression of the negative regulators CRY1 and CRY2, as well as PER1, PER2, and PER3. To assess the role of mouse PER3 (mPER3) in the circadian timing system, we...

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Source

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Identifiers

PMID: 10938103
DOI: 10.1128/MCB.20.17.6269-6275.2000
PMCID: PMC86101

Genes

PER3
BMAL1
CLOCK
CRY1
CRY2
PER1
PER2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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