Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of the VRK (vaccinia‐related kinase) gene family of p53 regulators in murine hematopoietic development

15 May 2003

Abstract excerpt

The vaccinia-related kinase (VRK) proteins are a new group of three Ser-Thr kinases in the human kinome. VRK proteins are upstream regulators of several transcription factors. VRK1 phosphorylates p53 in Thr-18 within the region of binding to mdm2 preventing their interaction. The tissue distribution of three genes is still largely unknown. In the present report the expression of these genes was analyzed during...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Microtubule and mitosis dynamics
Share to Nuclear Structure and Function

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12782311
DOI: 10.1016/s0014-5793(03)00501-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of the VRK (vaccinia‐related kinase) gene family of p53 regulators in murine hematopoietic developmentPMID 12782311Read ↗

p53 Stabilization and Accumulation Induced by Human Vaccinia-Related Kinase 1Semantic proximity Read ↗

VRK1 signaling pathway in the context of the proliferation phenotype in head and neck squamous cell carcinoma.Semantic proximity Read ↗

Comparative Interactomes of VRK1 and VRK3 with Their Distinct Roles in the Cell Cycle of Liver CancerSemantic proximity Read ↗

Alteration of the VRK1-p53 autoregulatory loop in human lung carcinomas.Semantic proximity Read ↗

p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loop.Semantic proximity Read ↗

Transiently truncated and differentially regulated expression of midkine during mouse embryogenesis.Semantic proximity Read ↗

mDYRK3 kinase is expressed selectively in late erythroid progenitor cells and attenuates colony-forming unit–erythroid developmentSemantic proximity Read ↗

VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer.Semantic proximity Read ↗

Protein kinase Cδ regulates vaccinia-related kinase 1 in DNA damage-induced apoptosis.Semantic proximity Read ↗

Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage responseSemantic proximity Read ↗

Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseasesSemantic proximity Read ↗

Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vitro and tumor growth and metastasis in vivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.