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Article

VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer.

Molecular and cellular biology - 1 Oct 2010

Fernández Isabel F, Blanco Sandra, Lozano José, Lazo Pedro A

Abstract excerpt

The epidermal growth factor (EGF)-ErbB-mitogen-activated protein kinase (MAPK) transcription signaling pathway is altered in many types of carcinomas, and this pathway can be regulated by new protein-protein interactions. Vaccinia-related kinase (VRK) proteins are Ser-Thr kinases that regulate se...

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Topics

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Share to Epidermal Growth Factor
Share to Immunoblotting
Share to MAP Kinase Signaling System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microscopy, Confocal

Share to Mitogen-Activated Protein Kinases

Share to Protein Kinases

Share to ras Proteins

Share to Receptor, ErbB-2

Source

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Identifiers

PMID: 20679487
DOI: 10.1128/MCB.01581-09
PMCID: PMC2950518

Genes

VRK2
EGF
KSR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20679487-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer.PMID 20679487Read ↗

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