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Article

Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases

1 Dec 2008

Abstract excerpt

Cyclin-dependent kinase 9 (Cdk9) is a cdc2-like serine/threonine kinase. The so-called Cdk9-related pathway comprises two Cdk9 isoforms (Cdk9-42 and Cdk9-55), cyclin T1, cyclin T2a, cyclin T2b and cyclin K. The association between Cdk9 and one of its cyclin partners forms a heterodimer, which is the main component of the positive transcription elongation factor (P-TEFb). The latter stabilizes the elongation...

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PMID: 19029809
DOI: 10.4161/cc.7.23.7122

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