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Article

VRK1 signaling pathway in the context of the proliferation phenotype in head and neck squamous cell carcinoma.

Molecular cancer research : MCR - 1 Mar 2006

Santos Claudio R, Rodríguez-Pinilla María, Vega Francisco M, Rodríguez-Peralto José L, Blanco Sandra, Sevilla Ana, Valbuena Alberto, Hernández Teresa, van Wijnen André J, Li Fengzhi, de Alava Enrique, Sánchez-Céspedes Montserrat, Lazo Pedro A

Abstract excerpt

The vaccinia-related kinase (VRK) proteins are a new family with three members in the human kinome. The VRK1 protein phosphorylates several transcription factors and has been postulated to be involved in regulation of cell proliferation. In normal squamous epithelium, VRK1 is expressed in the pro...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16547155
DOI: 10.1158/1541-7786.MCR-05-0212

Genes

VRK1
CDK2
CDK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16547155-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

VRK1 signaling pathway in the context of the proliferation phenotype in head and neck squamous cell carcinoma.PMID 16547155Read ↗

p53 Stabilization and Accumulation Induced by Human Vaccinia-Related Kinase 1Semantic proximity Read ↗

Alteration of the VRK1-p53 autoregulatory loop in human lung carcinomas.Semantic proximity Read ↗

Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage responseSemantic proximity Read ↗

Identification of VRK1 as a New Neuroblastoma Tumor Progression Marker Regulating Cell ProliferationSemantic proximity Read ↗

p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loop.Semantic proximity Read ↗

Protein kinase Cδ regulates vaccinia-related kinase 1 in DNA damage-induced apoptosis.Semantic proximity Read ↗

Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vitro and tumor growth and metastasis in vivoSemantic proximity Read ↗

Comparative Interactomes of VRK1 and VRK3 with Their Distinct Roles in the Cell Cycle of Liver CancerSemantic proximity Read ↗

VRK1 phosphorylates CREB and mediates <i>CCND1</i> expressionSemantic proximity Read ↗

Expression of the VRK (vaccinia‐related kinase) gene family of p53 regulators in murine hematopoietic developmentSemantic proximity Read ↗

VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer.Semantic proximity Read ↗

c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK).Semantic proximity Read ↗

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