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Article

Alteration of the VRK1-p53 autoregulatory loop in human lung carcinomas.

Lung cancer (Amsterdam, Netherlands) - 1 Dec 2007

Valbuena Alberto, Suárez-Gauthier Ana, López-Rios Fernando, López-Encuentra Angel, Blanco Sandra, Fernández Pedro L, Sánchez-Céspedes Montserrat, Lazo Pedro A

Abstract excerpt

Human VRK1 (vaccinia-related kinase 1) is a novel serine-threonine kinase that regulates several transcription factors, including p53, ATF2 and c-Jun; and its loss results in defects of cell proliferation. VRK1 stabilizes p53 and the accumulated p53 downregulates VRK1 forming an autoregulatory loop. Wild-type p53, but not mutant p53, was able to downregulate VRK1 in the A549 lung carcinoma cell line. VRK1...

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Share to Cell Line, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Intracellular Signaling Peptides and Proteins

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Share to Protein Serine-Threonine Kinases

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 17689819
DOI: 10.1016/j.lungcan.2007.06.023

Genes

VRK1
ATF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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