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Article

p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loop.

Molecular and cellular biology - 1 Jul 2006

Valbuena Alberto, Vega Francisco M, Blanco Sandra, Lazo Pedro A

Abstract excerpt

The stable accumulation of p53 is detrimental to the cell because it blocks cell growth and division. Therefore, increases in p53 levels are tightly regulated, mainly by its transcriptional target, mdm2, that downregulates p53. Elucidation of new signaling pathways requires the characterization o...

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Identifiers

PMID: 16782868
DOI: 10.1128/MCB.00069-06
PMCID: PMC1489172

Genes

VRK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16782868-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loop.PMID 16782868Read ↗

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