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Article

Efficiency of single-nucleotide polymorphism haplotype estimation from pooled DNA.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 2003

Yang Yaning, Zhang Jingshan, Hoh Josephine, Matsuda Fumihiko, Xu Peng, Lathrop Mark, Ott Jurg

Abstract excerpt

The efficiency of single-nucleotide polymorphism haplotype analysis may be increased by DNA pooling, which can dramatically reduce the number of genotyping assays. We develop a method for obtaining maximum likelihood estimates of haplotype frequencies for different pool sizes, assess the accuracy of these estimates, and show that pooling DNA samples is efficient in estimating haplotype frequencies. Although...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12777616
DOI: 10.1073/pnas.1237858100
PMCID: PMC165857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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