Article
Efficiency of single-nucleotide polymorphism haplotype estimation from pooled DNA.
Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 2003
Yang Yaning, Zhang Jingshan, Hoh Josephine, Matsuda Fumihiko, Xu Peng, Lathrop Mark, Ott Jurg
Abstract excerpt
The efficiency of single-nucleotide polymorphism haplotype analysis may be increased by DNA pooling, which can dramatically reduce the number of genotyping assays. We develop a method for obtaining maximum likelihood estimates of haplotype frequencies for different pool sizes, assess the accuracy...
Topics
- Algorithms
- Analysis of Variance
- Angiotensinogen
- DNA
- Gene Frequency
- Haplotypes
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Polymorphism, Single Nucleotide