Article
A study of the efficiency of pooling in haplotype estimation.
Bioinformatics (Oxford, England) - 15 Oct 2010
Kuk Anthony Y C, Xu Jinfeng, Yang Yaning
Abstract excerpt
MOTIVATION: It has been claimed in the literature that pooling DNA samples is efficient in estimating haplotype frequencies. There is, however, no theoretical justification based on calculation of statistical efficiency. In fact, the limited evidence given so far is based on simulation studies with small numbers of loci. With rapid advance in technology, it is of interest to see if pooling is still efficient when...
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