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Article

ARP-1/COUP-TF II determines hepatoma phenotype by acting as both a transcriptional repressor of microsomal triglyceride transfer protein and an inducer of CYP7A1.

The Journal of biological chemistry - 15 Aug 2003

Kang Sohye, Spann Nathanael J, Hui To Y, Davis Roger A

Abstract excerpt

L35 and FAO cells were derived as single cell isolates from H35 cells. Whereas L35 cells do not express microsomal triglyceride transfer protein (MTP), which regulates lipoprotein secretion, they express CYP7A1, which regulates bile acid synthesis from cholesterol. FAO cells display the opposite phenotype (i.e. expression of MTP but not CYP7A1). We examined the molecular basis of the transcriptional inactivation...

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Share to Carcinoma, Hepatocellular
Share to Cholesterol 7-alpha-Hydroxylase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Complementation Test

Share to Liver Neoplasms

Share to Receptors, Retinoic Acid

Share to Retinoid X Receptors

Share to Transcriptional Activation

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Source

Identifiers

PMID: 12777384
DOI: 10.1074/jbc.M304201200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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