Article
Identification of the human ApoAV gene as a novel RORalpha target gene.
Biochemical and biophysical research communications - 29 Apr 2005
Lind Ulrika, Nilsson Tina, McPheat Jane, Strömstedt Per-Erik, Bamberg Krister, Balendran Clare, Kang Daiwu
Abstract excerpt
Retinoic acid receptor-related orphan receptor-alpha (RORalpha) (NR1F1) is an orphan nuclear receptor with a potential role in metabolism. Previous studies have shown that RORalpha regulates transcription of the murine Apolipoprotein AI gene and human Apolipoprotein CIII genes. In the present study, we present evidence that RORalpha also induces transcription of the human Apolipoprotein AV gene, a recently...
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