Article
Chicken ovalbumin upstream-promoter transcription factor and E-box-binding proteins enhance thyroid-hormone responsiveness of the malic enzyme gene in avian hepatocytes.
The Biochemical journal - 15 Jan 2002
Wang Yutong, Zhang Yanqiao, Hillgartner F Bradley
Abstract excerpt
In chick embryo hepatocytes (CEH), stimulation of malic enzyme transcription by 3,3',5-tri-iodothyronine (T3) is mediated by a liver-specific and T3-inducible DNase I hypersensitive region (-3910 to -3640 bp) in the malic enzyme gene. Previous studies have shown that this region contains a cluster of five T3 response elements (T3REs), referred to as a T3 response unit (T3RU), plus three accessory elements that...
Topics
- Animals
- Binding Sites
- COUP Transcription Factors
- Cells, Cultured
- Chick Embryo
- DNA
- DNA-Binding Proteins
- Gene Expression Regulation
- Hepatocytes
- Malate Dehydrogenase
- Mutation
- Receptors, Steroid
- Sequence Homology, Nucleic Acid
- Transcription Factors