Article
Gene expression in hepatocyte-like lines established by targeted carcinogenesis in transgenic mice.
Experimental cell research - 1 May 1992
Antoine B, Levrat F, Vallet V, Berbar T, Cartier N, Dubois N, Briand P, Kahn A
Abstract excerpt
New hepatocyte-like cell lines (mhAT) were derived from the liver of a transgenic mouse expressing SV40 early genes under the direction of the liver-specific antithrombin III gene promoter (ATIII-TSV40). Their differentiated phenotypes were improved and stabilized by the use of liver-specific gro...
Topics
- Albumins
- Animals
- Antigens, Viral, Tumor
- Cell Line
- Gene Expression Regulation
- Liver
- Mice
- Mice, Transgenic
- Phenotype
- Phosphoenolpyruvate Carboxykinase (GTP)
- Promoter Regions, Genetic
- Pyruvate Kinase
- RNA, Messenger
- Trans-Activators
- Transfection
- Transferrin
- Tumor Cells, Cultured
- alpha-Fetoproteins