Article
Gene expression in hepatocyte-like lines established by targeted carcinogenesis in transgenic mice.
Experimental cell research - 1 May 1992
Antoine B, Levrat F, Vallet V, Berbar T, Cartier N, Dubois N, Briand P, Kahn A
Abstract excerpt
New hepatocyte-like cell lines (mhAT) were derived from the liver of a transgenic mouse expressing SV40 early genes under the direction of the liver-specific antithrombin III gene promoter (ATIII-TSV40). Their differentiated phenotypes were improved and stabilized by the use of liver-specific growth media (arginine-free, glucose-free, or low-fructose/glucose-free medium). The best differentiated lines display a...
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