Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms.

Journal of lipid research - 1 Aug 2010

Cai Shi-Ying, He Hongwei, Nguyen Trong, Mennone Albert, Boyer James L

Abstract excerpt

Cholesterol 7alpha-hydroxylase (CYP7A1) plays a key role in maintaining lipid and bile salt homeostasis as it is the rate-limiting enzyme converting cholesterol to bile acids. Deficiency of CYP7A1 leads to hyperlipidemia in man and mouse. Hyperlipidemia is often seen in patients when treated with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholesterol 7-alpha-Hydroxylase
Share to Gene Knockdown Techniques
Share to Hep G2 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatocytes

Share to Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

Share to Receptors, Cytoplasmic and Nuclear

Share to Retinoid X Receptor alpha

Share to Tretinoin

Source

Open in PubMed Open full text

Identifiers

PMID: 20338915
DOI: 10.1194/jlr.M005546
PMCID: PMC2903807

Genes

FGF19
PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20338915-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms.PMID 20338915Read ↗

Regulation of the Human Hydroxysteroid Sulfotransferase (SULT2A1) by RORα and RORγ and Its Potential Relevance to Human Liver DiseasesSemantic proximity Read ↗

Human FXR regulates SHP expression through direct binding to an LRH-1 binding site, independent of an IR-1 and LRH-1.Semantic proximity Read ↗

Transcriptional Regulation of the Human Sterol 12α-Hydroxylase Gene (CYP8B1)Semantic proximity Read ↗

Sumoylated PPARα mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in miceSemantic proximity Read ↗

Dual Mechanisms for Repression of the Monomeric Orphan Receptor Liver Receptor Homologous Protein-1 by the Orphan Small Heterodimer PartnerSemantic proximity Read ↗

Liver receptor homolog 1 transcriptionally regulates human bile salt export pump expressionSemantic proximity Read ↗

Hepatocyte nuclear factor 4α (HNF4α) in coordination with retinoic acid receptors increases all-trans-retinoic acid-dependent CYP26A1 gene expression in HepG2 human hepatocytes.Semantic proximity Read ↗

The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor.Semantic proximity Read ↗

Prospero-Related Homeobox (Prox1) Is a Corepressor of Human Liver Receptor Homolog-1 and Suppresses the Transcription of the Cholesterol 7-α-Hydroxylase GeneSemantic proximity Read ↗

Biological and clinical implications of retinoic acid-responsive genes in human hepatocellular carcinoma cellsSemantic proximity Read ↗

Identification of Liver Receptor Homolog-1 as a Novel Regulator of Apolipoprotein AI Gene TranscriptionSemantic proximity Read ↗

Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.