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Article

The COUP-TFII variant lacking a DNA-binding domain inhibits the activation of the Cyp7a1 promoter through physical interaction with COUP-TFII.

The Biochemical journal - 1 Jun 2013

Yamazaki Tomoko, Suehiro Jun-ichi, Miyazaki Hideki, Minami Takashi, Kodama Tatsuhiki, Miyazono Kohei, Watabe Tetsuro

Abstract excerpt

The COUP-TFII (chicken ovalbumin upstream promoter-transcription factor II) nuclear receptor, which is composed of a DNA-binding domain and a ligand-binding domain, exerts pleiotropic effects on development and cell differentiation by regulating the transcription of its target genes, including Cyp7a1 (cytochrome P450, family 7, subfamily a, polypeptide 1), which plays important roles in catabolism of cholesterol...

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Source

Identifiers

PMID: 23458092
DOI: 10.1042/BJ20121200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The COUP-TFII variant lacking a DNA-binding domain inhibits the activation of the Cyp7a1 promoter through physical interaction with COUP-TFII.PMID 23458092Read ↗

Characterization of the Human Cytochrome P4502D6 PromoterSemantic proximity Read ↗

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Identification of COUP-TFII Orphan Nuclear Receptor as a Retinoic Acid–Activated ReceptorSemantic proximity Read ↗

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HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1).Semantic proximity Read ↗

The Chicken Ovalbumin Upstream Promoter-Transcription Factor II Negatively Regulates the Transactivation of Androgen Receptor in Prostate Cancer CellsSemantic proximity Read ↗

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Ubc9 interacts with chicken ovalbumin upstream promoter-transcription factor I and represses receptor-dependent transcription.Semantic proximity Read ↗

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