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Article

Retinoic Acid Receptor-Mediated Induction of ABCA1 in Macrophages

15 Oct 2003

Abstract excerpt

ABCA1, the mutant molecule in Tangier Disease, mediates efflux of cellular cholesterol to apoA-I and is induced by liver X receptor (LXR)/retinoid X receptor (RXR) transcription factors. Retinoic acid receptor (RAR) activators (all-trans-retinoic acid [ATRA] and TTNPB) were found to increase ATP-binding cassette transporter 1 (ABCA1) mRNA and protein in macrophages. In cellular cotransfection assays, RARgamma/RXR...

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PMID: 14560020
DOI: 10.1128/mcb.23.21.7756-7766.2003

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