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Article

Vertebrate p34cdc2 phosphorylation site mutants: effects upon cell cycle progression in the fission yeast Schizosaccharomyces pombe.

Journal of cell science - 1 May 1992

Krek W, Marks J, Schmitz N, Nigg E A, Simanis V

Abstract excerpt

We have used the fission yeast Schizosaccharomyces pombe to analyse the effects of in vitro mutagenesis of the four known phosphorylation sites in the chicken p34(cdc2) protein, Thr 14, Tyr 15, Thr 161 and Ser 277, upon cell cycle progression. We have studied both the effect of overexpression of mutant proteins in a cdc2+ background and assayed their ability to rescue null and temperature-sensitive alleles of...

Topics

Amino Acid Sequence
Amino Acids
Animals
Binding Sites
CDC2 Protein Kinase
Cell Cycle
Chickens
Gene Expression Regulation
Molecular Sequence Data
Mutagenesis
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphorylation

Schizosaccharomyces

Source

Identifiers

PMID: 1500441
DOI: 10.1242/jcs.102.1.43

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1500441-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Vertebrate p34cdc2 phosphorylation site mutants: effects upon cell cycle progression in the fission yeast Schizosaccharomyces pombe.PMID 1500441Read ↗

Regulation of p34cdc2 protein kinase activity by phosphorylation and cyclin binding.Semantic proximity Read ↗

A phosphorylation site mutant of Schizosaccharomyces pombe cdc2p fails to promote the metaphase to anaphase transition.Semantic proximity Read ↗

Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function.Semantic proximity Read ↗

The function of the chicken p34CDC2 protein kinase in fission yeast is cold sensitive for cell cycle progression through the G1 phase and temperature sensitive for traversal of mitosis.Semantic proximity Read ↗

Regulation of cdc2 activity in Schizosaccharomyces pombe: the role of phosphorylation.Semantic proximity Read ↗

Isolation, characterisation and molecular cloning of new mutant alleles of the fission yeast p34cdc2+ protein kinase gene: identification of temperature-sensitive G2-arresting alleles.Semantic proximity Read ↗

Genetic analysis of human p34CDC2 function in fission yeast.Semantic proximity Read ↗

Cold-sensitive mutants of p34cdc2 that suppress a mitotic catastrophe phenotype in fission yeast.Semantic proximity Read ↗

Analysis of the role of phosphorylation in fission yeast Cdc13p/cyclinB function.Semantic proximity Read ↗

The Schizosaccharomyces pombe cdc14 gene is required for septum formation and can also inhibit nuclear division.Semantic proximity Read ↗

FANCG is phosphorylated at serines 383 and 387 during mitosis.Semantic proximity Read ↗

Identification of residues in fission yeast and human p34cdc2 required for S-M checkpoint control.Semantic proximity Read ↗

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