Article
Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216.
Science (New York, N.Y.) - 5 Sept 1997
Peng C Y, Graves P R, Thoma R S, Wu Z, Shaw A S, Piwnica-Worms H
Abstract excerpt
Human Cdc25C is a dual-specificity protein phosphatase that controls entry into mitosis by dephosphorylating the protein kinase Cdc2. Throughout interphase, but not in mitosis, Cdc25C was phosphorylated on serine-216 and bound to members of the highly conserved and ubiquitously expressed family o...
Topics
- 14-3-3 Proteins
- Amino Acid Sequence
- Cell Cycle Proteins
- Checkpoint Kinase 1
- DNA Damage
- DNA Replication
- G2 Phase
- Gamma Rays
- HeLa Cells
- Humans
- Jurkat Cells
- Mitosis
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Phosphoserine
- Protein Kinases
- Proteins